Open Question: should IPC hire Nathaniel Wu? why and why not? Please help me!!!!?
THE CASE OF NATHANIEL Wu
Nathaniel Wu is a top-notch microbiologist. Now 30 years old, he has spent several years
working in one of the best research laboratories in the world and has developed an
excellent reputation as a creative researcher and hard worker. Following the birth of their
son six months ago, Nathaniel and his 29-year-old wife decided it was time for Nathaniel
to seek a job that could help them settle down and become financially secure. Thus, it
was with great interest that Nathaniel read the following advertisement in a scientific
journal:
Intercontinental Pharmaceutical Corporation (IPC) of New Jersey is seeking highly
qualified scientists to join a unique research team. IPC is prepared to invest up to $20
million in setting up and supporting a team of researchers to conduct creative research to
find new treatments and cures for diseases ranging from AIDS to heart disease and the
common cold. Because IPC will commit $20 million to this research effort, we will
require those selected for this special research project to commit to a long-term
employment contract. Interested applicants should send information to Dr. Anna Peters
at IPC.
This was the type of job Nathaniel had always hoped for, and he applied immediately.
Before long, IPC invited Nathaniel to come to its headquarters and interview for a
position on this special research team.
Dr. Peters, the head of the research committee, led a series of interviews with Nathaniel
and three other qualified applicants. Although the other three applicants also were well-
qualified, they did not seem to share the same determination and drive as Nathaniel Wu.
She listened carefully when Nathaniel presented his latest research findings to IPC
scientists. They, too, were impressed with Nathaniel?s knowledge, research skills, and
potential for contributing to the special goals of the research team.
Nathaniel sounded like the type of applicant who could have a long and productive career
with IPC, and he seemed to be the sort of team player IPC was seeking.
Because Nathaniel was a top-quality research scientist, there was a high likelihood that
his knowledge and research efforts might result in the type of discoveries for new drugs
and treatments that were the goal of this special research project. Such discoveries and
products could improve the quality of life for countless individuals and dramatically
increase earnings for IPC. The investment by IPC of several million dollars to set up and
support a laboratory for Nathaniel and to pay his salary while he worked seemed like a
good one.
There was, however, one additional bit of information that Dr. Peters had before her as
she considered her recommendation to the Employment Selection Committee. As part of
the application process, Nathaniel had submitted a blood sample to determine his genetic
profile, as had all other applicants. The profile showed that Nathaniel had the allele for
Huntington disease. When asked about this, Nathaniel revealed that he knew nothing
about his family history because he had been adopted as an infant. After thorough genetic
counseling about the implications of this news, Nathaniel still wanted the job at IPC.
Page 2
To have a clearer picture of the impact of this new information on her recommendation,
Dr. Peters had requested information from the IPC medical director. The report included
the following information:
Huntington disease (HD) is an autosomal dominant genetic disorder with an
incidence in North America of 1 in 20,000. It is extremely rare in Orientals.
Individuals who have the allele for HD will, at some point, develop symptoms
of the disease; the usual age of onset is between 35 and 45 years. The disorder
is characterized by progressive degeneration of nerve cells in the central
nervous system. The patient begins to have involuntary jerky or writhing
movements of the arms and legs and facial grimacing. Changes in
personality, including inappropriate laughter, crying, episodes of anger,
memory loss, and bizarre, almost schizophrenic behavior may precede or
follow the movement disorder; the clinical picture is highly variable. The
disorder is fatal, with death commonly occurring when the patient is in his or
her 50s, and the patient usually enters an almost vegetative state for the last
few years of life.
Although we cannot predict the precise age of onset of these symptoms, the fact that
Nathaniel has lived to age 30 without any identifiable symptoms means that he has
approximately a 60 percent likelihood of onset by age 40. Soon after the onset of
symptoms, a person with Huntington disease most likely would be unable to perform
safely or productively in a laboratory setting. Medical care for a patient with HD can be
extremely costly, requiring long-term care in a hospital or other medical-care facility.
Without testing Mrs. Wu, we can predict that their son has a 50 percent chance of having
the allele

Tue, 21 Apr 2009 19:37:58 GMT

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